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Christopher Cirnigliaro, PhD, CBDT
Investigator
James J. Peters VA Medical Center
For more than 24 years, Dr. Christopher M. Cirnigliaro has served as an investigator and bone densitometry technician at the James J. Peters VA Medical Center Spinal Cord Damage Research Center. His primary research interests focus on the diagnosis, prevention, and treatment of bone loss in individuals living with acute and chronic spinal cord injury. Over the course of his career, Dr. Cirnigliaro has been a co-investigator on more than ten clinical trials examining post-injury bone loss. He has served as senior research coordinator and co-investigator on multiple studies involving the bisphosphonates pamidronate and zoledronic acid, as well as two recent trials combining the RANKL inhibitor denosumab with the anti-sclerostin agent romosozumab to prevent and treat bone loss following spinal cord injury. In all of these studies, Dr. Cirnigliaro has developed protocol designs for image acquisition and analysis, and has led statistical analyses of bone mineral density data derived from dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). Dr. Cirnigliaro is currently a recipient of the VA Rehabilitation Research and Development & Translation Career Development Award-2. His ongoing research investigates the effects of exoskeleton-assisted walking and transcutaneous spinal cord stimulation on imaging and serum biomarkers of skeletal muscle mass and bone strength in individuals with chronic spinal cord injury.