Atypical Femur Fracture: Identification and Management | Atypical Femoral Fracture: An Update
Atypical Femur Fracture: Identification and Management
E. Michael Lewiecki, MD, FACP, FACE, CCD
Saturday, April 11, 2026, 2:00pm to 2:30pm Eastern Time (NY/USA)
Description
AFFs are associated with some osteoporosis treatments and may occur without any treatment. The risk of AFF for most patients is very low and can be minimized with appropriate care. This presentation will address strategies for early recognition AFF, treatment of incomplete and complete AFF, and management of osteoporosis after AFF.
Objectives
- Identify standards for diagnosing atypical femur fractures (AFF)
- Describe risk factors for AFF
- Discuss strategies for prevention of AFF
Atypical Femoral Fracture: An Update
WuQiang Fan, MD, PhD
Saturday, April 11, 2026, 2:30pm to 3:00pm Eastern Time (NY/USA)
Objectives
In this session, we will:
- Review the risks, epidemiological patterns, and clinical features of atypical femoral fractures (AFFs).
- Discuss differential management of AFF linked to bisphosphonate or denosumab therapy, including areas of uncertainty.
- Evaluate the clinical implications of current AFF knowledge in the context of anti-osteoporosis pharmacotherapy.
E. Michael Lewiecki, MD, FACP, FACE, CCD
Director
New Mexico Clinical Research & Osteoporosis Center, Inc.
Dr. Lewiecki is Director of New Mexico Clinical Research & Osteoporosis Center and Director of Bone Health ECHO at University of New Mexico Health Sciences Center in Albuquerque, NM. He is a consultant in osteoporosis and other metabolic bone diseases, supervisor and interpreter of bone density studies, and an educator with a special interest in the evaluation and treatment of osteoporosis and metabolic bone diseases. He has been principal investigator for many osteoporosis clinical trials and is author of over 390 publications in peer-reviewed medical journals with more than 45,000 citations, as well as books, book chapters, and online publications. He is past president of the International Society for Clinical Densitometry (ISCD) and founding president of the Osteoporosis Foundation of New Mexico (OFNM). He is program director of the annual Santa Fe Bone Symposium, the flagship activity of the OFNM. He is Review Editor for Osteoporosis International and is on the editorial board of the Journal of Clinical Densitometry. He has participated with development of ISCD Official Positions (2002, 2004, 2006, 2008, 2011, 2013, 2015, 2019, 2023), International Workshops on the Evaluation and Management of Primary Hyperparathyroidism (2009, 2014, 2022), and osteoporosis treatment guidelines of the National Osteoporosis Foundation / Bone Health & Osteoporosis Foundation (2008, 2014, 2022) and the American Association of Clinical Endocrinologists (2016, 2020), as well as with many other workshops and consensus statements in the field of metabolic bone disease. He has received national and international awards that include the 2021 “Dr. John P. Bilezikian ISCD Global Leadership Award”, and the 2021 “Lawrence G. Raisz Memorial Lecture Award” with the Bone Health & Osteoporosis Foundation, and the 2025 “Santa Fe Bone Symposium Award” in recognition of pioneering contributions to improving skeletal health. He was listed by Expertscape as the #1 osteoporosis expert in the world during the years 2011-2021. ScholarGPS currently lists him as #3 worldwide osteoporosis scholar for the previous 5 years.
WuQiang Fan, MD, PhD
Director of Fracture Liaison Service, Assistant Professor of Medicine
Massachusetts General Hospital, Harvard Medical School
Dr. WuQiang Fan (pronounced as “Wu-Chiang Fan”) earned his medical degree from Zhejiang University School of Medicine in China. He subsequently completed his PhD in molecular biology at Kyushu University in Japan, where he investigated steroid hormone receptor signaling and transcriptional regulation. He then pursued postdoctoral research on diabetes and insulin signaling at the University of California, San Diego School of Medicine, before undertaking internal medicine residency training at Drexel University College of Medicine. In 2016, he began his endocrinology fellowship at Massachusetts General Hospital (MGH), where he remained on faculty following graduation. His clinical interests focus on metabolic bone disease and diabetes. He currently serves as Director of the MGH Fracture Liaison Service and Fracture Secondary Prevention Program, and as one of the Associate Program Directors of the MGH Endocrinology Fellowship Training Program. He is an Assistant Professor of Medicine at Harvard Medical School.