The Current State of Research on the use of Non-BMD Biomarkers to Determine Fracture Risk

Session approved for 1 ASRT Category A Credit
Session approved for up to 1 AMA PRA Category 1 Credits™

This session duration is 55 minutes.

Review several non-BMD approaches to assess skeletal fragility and fracture risk.

Learning Objectives:

  • Identify the determinants of bone strength adn what can be measured by non-invasive imaging
  • Define the current state of the use opportunistic CT, including Ct-based finite element analysis of bone strength, to identify individuals at high risk for fracture
  • Identify the potentiuse of REMS ultrasound technology to identify individuals with low BMD

Mary L. Bouxsein, PhD

Associate Professor

Harvard Medical School

Dr. Bouxsein received her doctorate in Mechanical Engineering from Stanford University and completed a post-doctoral fellowship at the Orthopedic Biomechanics Laboratory at Harvard Medical School. She is an Associate Professor of Orthopedic Surgery at Harvard Medical School and the Director of the Center for Advanced Orthopedic Studies at Beth Israel Deaconess Medical Center. Dr. Bouxsein is also a faculty member in the Harvard-MIT Health Sciences and Technology Program and in the MIT Bioastronautics Program. Dr. Bouxsein has received several awards, including the Fuller Albright Award from the American Society for Bone and Mineral Research, Herbert Fleisch Award from the International Osteoporosis Foundation for excellence in basic/translational bone research and the A. Clifford Barger Award for Excellence in Mentorship from Harvard Medical School. She currently serves as a board member for the International Osteoporosis Foundation, and a Councilor of the American Society for Bone and Mineral Research. She has published over 275 peer-reviewed articles and 40 book chapters and invited reviews. Dr. Bouxsein’s research focuses on understanding skeletal fragility in osteoporosis and diabetes from a biomechanics viewpoint, and includes research into advanced skeletal imaging and musculoskeletal modeling.


AgNovos Healthcare (Self) : Consultant (Status: Ongoing); Keros Therapeutics (Self) : Advisory Board (Status: Ongoing)

Karen L. Troy, PhD, CBDT (Moderator)



Karen L Troy, PhD, CBDT, is a Professor of Biomedical and Mechanical Engineering at Worcester Polytechnic Institute. Her research focuses on the interaction between skeletal loading and bone adaptation. She uses a combination of medical imaging, computational modeling, and biomechanical techniques to better understand the consequences of disuse osteoporosis, healthy physiologic adaptation, and overuse injury in healthy and clinical populations including individuals with spinal cord injury and those participating in various sports. She developed patient-specific modeling and quantitative image analysis techniques to evaluate clinical interventions that target bone health, and has worked with several task forces to develop bone density screening and clinical practice guidelines specific to individuals with spinal cord injury.


Ossanex (Self) : Shareholder (Status: Ongoing); Scipher Medicine (Spouse/Partner) : Employment (Status: Ongoing)


Recorded Archive
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03/31/2022 at 2:00 PM (EDT)   |  55 minutes
03/31/2022 at 2:00 PM (EDT)   |  55 minutes
10 Questions
Medical Certificate
Up to 1.00 medical credits available  |  No certificate available
Up to 1.00 medical credits available  |  No certificate available